Nature-Inspired Drugs: Expanding Horizons of Contemporary Therapeutics

Expanding horizons

Colchicine--expanding horizons.

To say that the once very limited indications for colchicine have undergone a subtle but definite and dramatic change in recent years would not be an overstatement. This old drug, which has been known for centuries, was used for relieving and preventing acute attacks of gouty arthritis for over 200 years, but until recently, no other clinical uses had been established. The 1985 edition of Good-...

Expanding cerebellar horizons.

Anatomical connections must underly neuronal function. A new study by Middleton and Strick shows that the cerebellum projects to the dorsal prefrontal cortex of the monkey. This could provide the basis for cerebellar modulation of cognitive processes.

Expanding Horizons of Diagnostic Imaging

Until 25 years ago X-rays were the only means of imaging the inside of the body. It has recently been decided to screen all women between the ages of 50 and 64 for breast cancer and so Professor Wells chose mammography for his example of radiology. The difficulties were illustrated by a case in which a tumour had been shown on mammography but the surgeon at operation had failed to find it. 4 ye...

Expanding Therapeutic Horizons of Bevacizumab

Background: In the past few years there has been an increased interest in the repurposing of already approved pharmacotherapies for other uses. Bevacizumab is the most widely off-label used antiangiogenic in retinal ophthalmology, recently highlighting new targets in other ocular disorders. Objective: The objective of this review is to evaluate the evidence and discuss the rationale behind the ...